Abstract— The aim of this study was to investigate the relationship between locus of control (internal - external) and the self-efficacy beliefs of Yazd University of medical science. The research population consisted of the Yazd Central University of Medical Sciences staff 534 people using Cochran formula the sample size was 220 people. Instrument was two questionnaires self-control and self-efficacy and the validity of the questionnaires was 0.82, 0.87, and reliability 0.8260 and 0.880 respectively obtained. To investigate the hypothesis Pearson, Spearman, log-linear regression tests used. The results showed that there is a direct and meaningful relationship between internal locus of control and self-efficacy beliefs. However, there was not a meaningful relationship between external locus of control and self-efficacy. To achieve the organization's employees with high self-efficacy, locus of control considered as a factor-affecting self-efficacy.